Stress in Action capitalizes on the fast advances in technology and big data analytics to move stress research from the lab to daily life. A theoretical framework of daily life stress will be developed using the novel insights from ambulatory assessments in large, long-running Dutch cohorts and from experimental validation studies.

This generates novel, mechanistic understanding of 1) how responses to daily life stress arise from the temporal, dynamic interplay between context and person-specific factors, 2) how daily life stress can be reliably measured in a specific individual in real-time, and 3) how and when potential beneficial stress-response mechanisms turn into detrimental effects on mental and cardiometabolic health. This will enable the development of novel monitoring and intervention strategies to track and reduce daily life stress and its health impact.